Estrogen and the Transgender Woman

Testosterone and estrogen are the hormones associated with gender. The average male, female and everyone in between have bodies that run on and need both. Today we are going to explore estrogen and the effects of it on the transgender female. Please note before we proceed that if you are currently undergoing or thinking of undergoing hormone replacement therapy with estrogen that we strongly recommend you do so under the care of a physician. There can be many dangers and health risks if estrogen is not administered and monitored properly.
Hormone Replacement Therapy with estrogen is the process of administering the hormone to “male to female” transgender patients in order to induce and maintain the development of female secondary sex characteristics. Though estrogen cannot reverse the effects of puberty, HRT with estrogen can help develop female characteristics and make a patient look more like the female gender they identify with. It causes significant social and psychological changes while affecting your mood, energy, appearance and overall health. Though not a full cure it is very effective at treating patients with gender dysphoria. Estrogen can be administered by injections, pills, patches and subdermal pellet implants.
Both testosterone and estrogen are needed for healthy bone and to prevent osteoporosis. Estrogen is the predominant sex hormone that slows bone loss. The hips will rotate slightly forward due to changes in the tendons so hip discomfort is not uncommon. If estrogen therapy is conducted prior to the pelvis ossification that occurs around the age of 25, the pelvic outlet and inlet open slightly. This widening will also widen the femora as they are connected to the pelvis. The pelvis will still have some masculine characteristics by default but the end result will be wider hips than a normal male and closer to a cis female.

The Truth Behind the Biology of Sex



She said, “You may have heard before that gender is socially constructed, while sex is biological. But I’m here to tell you that what you’ve heard isn’t true. Sex is socially constructed too. So are you ready for the truth? Are you going to take the red pill or the blue pill?”
Three years later, I was diagnosed by my gynecologist with polycystic ovarian syndrome (PCOS), which means that my body produces hormones intermediate between “typical men” and “typical women.” What I learned from Kiki gave me context in which to understand what this meant about my body and who I am. But it’s still very hard for me to talk about. My hormones affect me in ways that are hard to see, so even most of my lovers don’t know. I can count the number of people in my personal life who know this about me on my two hands.
I picked the red pill. If you read on, you can take the red pill too.
The problem with calling sex “biological” is that biology is complicated. Hardly anything in biology fits into two neat categories like “male” and “female.” To give you an idea of how complicated sexual development really is, let’s go to the very beginning. How do sexual characteristics develop in a human embryo?
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Transsexual gene link identified



Australian researchers have identified a significant link between a gene involved in testosterone action and male-to-female transsexualism.
DNA analysis from 112 male-to-female transsexual volunteers showed they were more likely to have a longer version of the androgen receptor gene.
The genetic difference may cause weaker testosterone signals, the team reported in Biological Psychiatry.
However, other genes are also likely to play a part, they stressed. Increasingly, biological factors are being implicated in gender identity.
One study has shown that certain brain structures in male-to-female transsexual people are more "female like".
In the latest study, researchers looked for potential differences in three genes known to be involved in sex development - coding for the androgen receptor, the oestrogen receptor and an enzyme which converts testosterone to oestrogen.
Comparison of the DNA from the male to female transsexual participants with 258 controls showed a significant link with a long version of the androgen receptor gene and transsexualism.
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